Congenital syphilis is a transplacental fetal infection with T.pallidum 

Symptoms & Signs: 

Early symptoms (within 2 years of life): flu-like syndrome associated with nasal discharge (snuffles), maculopapular rash, anemia, jaundice, hepatosplenomegaly,hydrocephalus, lymphadenopathy, chorioretinitis 

Late symptoms (after 2 years of life): Saddle nose, saber shins, short maxilla, frontal bossing, high palatal arch, eighth nerve deafness, interstitial keratitis, triangular or peglike teeth (Hutchinson teeth)

-The most common eye lesion in congenital syphilis: interstitial keratitis

-treatment of the mother during pregnancy prevents congenital syphilis 

-All infants born to mothers with positive syphilis tests should have RPR or VDRL test 

Neurosyphilis, infection of the CNS by T.pallidum can occur at any stage of infection 

Symptoms & Signs 

Fever,  eye pain, redness, photophobia, vision loss, uveitis, iritis, hearing loss,  cranial nerve abnormalities (especially cranial nerves II, III, IV, VI, VII, and VIII), meningismus 

Tabes dorsalis: It results from damage to the posterior columns of the spinal cord 

It presents with sensory ataxia, impairment of proprioception and vibration sense, a wide-based gait with impaired balance that is exacerbated by eye closure (the Romberg sign), muscular hypotonia, hyporeflexia, paresthesias, analgesia, or sharp, agonizing,  (‘shooting’/ ‘lightning) pains in the muscles of the leg, painful bladder spasms, urinary incontinence, impotence,  footdrop, and loss of reflexes.

-It can be accompanied by an Argyll Robertson pupil (which accommodates, but does not react to, light, light-near disassociation phenomenon) and optic atrophy 

-Painless trophic ulcers may develop over pressure points on the feet. 

-Sensory loss and hypotonicity can lead to the occurrence of hypertrophic (Charcot) joints.