Secondary syphilis occurs due to systemic dissemination of spirochetes in a third of primary patients 

Systemic symptoms: Fever, malaise, sore throat, weight loss, muscle aches and generalized lymphadenopathy 

Rash: Generalized maculopapular rash on the trunk, palms and soles 

Condyloma lata: fused, weeping, warty, papules on the moist areas of the skin and mucous membranes

Other manifestations: ‘moth-eaten alopecia’, Annular papules and plaques around the mouth and nose (nickels and dimes), split papule at the angle of the mouth, hepatitis, nephritis