Toxoplasma gondii is one of the most common pathogens to cause chorioretinitis (a posterior uveitis) in immunocompetent hosts. Immunocompetent adults with ocular toxoplasmosis can present with visual loss, especially if chorioretinitis affects the macular region. Floaters are often the presenting sign if chorioretinitis is extramacular. In addition, certain asymptomatic patients may have scarring noted on routine examination without evidence of active chorioretinitis.
Ocular disease can be due to acute infection or reactivation disease.
●Acute ocular disease – Acute ocular disease can be seen in adults and is also associated with congenital infection. It is estimated that in the United States, about 2 percent of Toxoplasma-infected people develop chorioretinitis, which may not be recognized in the acute phase but found later as a retinal scar. Children with congenital toxoplasmosis can develop retinochoroiditis associated with visual impairment.
●Reactivation disease – Those with reactivation disease are infected either in utero or postnatally. Patients with reactivation disease often have bilateral involvement, in comparison to adults with acute infection who typically present with unilateral ocular disease. Patients older than 40 years of age are at higher risk of recurrence than younger patients, and a relapsing and remitting course can develop after a prolonged disease-free interval. In immunocompetent hosts, reactivations are almost always chorioretinitis and not lymphadenopathy or febrile illness.
It is well established that T. gondii can be divided into different genotypes and that different genotypes differ in pathogenicity. This explains why acquired T. gondii infection in South and Central America has high rates of posterior uveitis compared with other geographic areas.
Diagnosing ocular disease — Ocular toxoplasmosis should be considered in a patient who presents with visual loss or floaters. The diagnosis of ocular disease is typically suggested by findings on ophthalmologic examination and supported by serologic testing and/or aqueous humor analysis.
●Exam findings – Findings on ophthalmologic examination usually include extensive iritis and vitritis, accompanied by whitish retinal lesions representing chorioretinitis. However, chorioretinitis and choroidal neovascularization may be masked by the vitreous inflammation and require angiography for detection.
●Serologic testing – Serologic testing to detect the presence of IgM and IgG antibodies should be performed to support the diagnosis of ocular toxoplasmosis.
●Aqueous humor analysis – Aqueous humor analysis (eg, polymerase chain reaction [PCR] or antibody testing), if available, can also be used to help diagnose intraocular disease if the diagnosis is unclear (eg, atypical exam findings and/or negative serology). The use of aqueous humor analysis was evaluated as a diagnostic method in 137 immunocompetent patients with posterior uveitis resulting from a suspected infectious etiology. Intraocular antibody production and PCR were used to test for a variety of pathogens including T. gondii, herpes simplex virus, varicella zoster virus, and cytomegalovirus. Of the 37 patients with positive results, 75 percent had evidence of toxoplasma infection; most were diagnosed using measurements of intraocular antibody production.
Treatment — The decision to treat chorioretinitis depends upon several factors, including: the degree of inflammation; the patient’s visual acuity; and the size, location, and persistence of the lesion. The treatment of ocular disease should be done in conjunction with an ophthalmologist experienced in the diagnosis and treatment of chorioretinitis or uveitis.
Indications — Patients with evidence of inactive ocular toxoplasmosis do not require treatment. However, we suggest antimicrobial treatment (with or without adjunctive steroids) for patients with iritis, vitritis, or chorioretinitis if the lesions have one of the following characteristics :
●They are located within the vascular arcades
●They are adjacent to the optic disk
●They are larger than 2 optic disc diameters
●They have an atypical presentation
We also treat individuals infected in South or Central America with a more pathogenic strain of T. gondii.
Although most cases of active ocular toxoplasmosis resolve spontaneously over the course of four to eight weeks, limited data suggest that systemic antimicrobial therapy (with or without glucocorticoids) is associated with a reduction in active retinochoroiditis and/or improved vision. As an example, 149 patients with ocular toxoplasmosis were evaluated in a prospective multicenter study. Patients with central lesions were treated with one of three different antimicrobial regimens in combination with glucocorticoids, whereas those with peripheral lesions did not receive systemic therapy. Approximately half of the 35 patients treated with a pyrimethamine-containing regimen had a reduction in the size of the retinal inflammatory lesion compared with 20 percent (8 of 41) who did not receive systemic therapy.
Antimicrobial therapy for ocular disease — Ocular toxoplasmosis is treated with similar agents as those used for systemic disease. The duration depends upon the clinical response.
Preferred regimens — Our preferred regimen for nonpregnant adults with chorioretinitis is pyrimethamine (100 mg) plus sulfadiazine (2 grams) given as a single loading dose on the first day of treatment. This is followed by pyrimethamine (25 mg daily) plus sulfadiazine (500 mg four times daily) plus leucovorin (10 mg daily) for a minimum of six weeks.
If a pyrimethamine-containing regimen cannot be used, we administer trimethoprim-sulfamethoxazole (TMP-SMX; 160 mg TMP/800 mg SMX) twice daily for six weeks. After the first six weeks, we then administer therapy with one double-strength tablet taken every other day for one year. This suppressive regimen has been found to reduce the risk of recurrent disease.
Alternative regimens — If a patient is intolerant to first-line regimens, we administer atovaquone (750 mg four times a day) in combination with pyrimethamine (100 mg loading dose followed by 25 mg daily) plus leucovorin (10 mg per day) for a minimum of six weeks. Atovaquone can be given alone if pyrimethamine is not tolerated or not available; however, it must be given for at least three months.
Azithromycin 500 mg daily for a minimum of six weeks is another option. This regimen has been shown to be effective, but resolution of findings is slower than with the pyrimethamine-sulfadiazine combination.
Intravitreal clindamycin (0.1 mg/0.1 mL) with one to three injections administered over a period of six weeks can also be used. The number of injections is based upon disease activity on examination. This regimen can be difficult for a nonretina specialist to perform.
Adjunctive glucocorticoids — We administer glucocorticoids to patients with significant vitreous inflammation and retinal vasculitis to help preserve vision. There are no definitive data to guide the best way to administer glucocorticoids.
●We typically initiate prednisone (40 mg once a day) three days after antimicrobial therapy has been started. We delay glucocorticoid therapy by three days to reduce the organism burden and minimize the likelihood that glucocorticoids will exacerbate the infection. This approach has been used in clinical trials evaluating different treatment regimens for ocular disease.
●We continue the 40 mg daily dose until the inflammation clears up in the eye, and the posterior pole and vitreous normalize, which can take a few weeks. After that, we taper the glucocorticoids (eg, prednisone 30 mg for one week, 20 mg for one week, 10 mg for two weeks, 5 mg for two weeks).
Frequency of follow-up — Patients on therapy require frequent ophthalmologic examinations to monitor the response to therapy. The frequency of follow-up depends upon the proximity of the lesion to the central vision. As an example, patients with central lesions should be seen at least once weekly.
Duration of treatment — Patients with ocular disease should be treated for a minimum of six weeks. Ocular findings that support treatment discontinuation include resolution of inflammation and retinitis. Lesion activity and cessation of vasculitis on fluorescein angiography are also useful to help if determine if treatment can be stopped.
The ultimate duration also depends upon the specific regimen. Certain agents (eg, TMP-SMX, atovaquone monotherapy) require a longer course of treatment than others.
1/8 Women will develop breast cancer.
Breast Cancer: Biennial screening
50-74 years: mammography
over 75 years: Insufficient evidence to recommend mammography.
If you want to discuss mammography orders, please visit our clinic.
But the general guidelines are:
Essential elements of management for breast cancer survivors who have completed active treatment and have no evidence of disease are cancer surveillance, encouragement of adherence with ongoing treatment and lifestyle recommendations, treatment of medical and psychosocial consequences of cancer and its therapy, and care coordination between specialists and primary care providers.
●Survivor follow-up should include updated history, regular physical examination, and breast imaging (ie, mammography). The follow-up should not only focus on cancer surveillance, but also on any late-treatment related complications, psychosocial issues, and occupational problems.
●All women with breast cancer should be counseled about the role of genetic testing and counseling.
●Laboratory studies or radiologic imaging to screen for distant recurrence in asymptomatic patients should not be performed.
●All breast cancer survivors should pursue a healthy lifestyle that includes following a prudent diet, pursuing or maintaining an active exercise program, minimizing alcohol intake, and refraining from smoking.
●Treatment may affect many aspects of sexuality, and breast cancer survivors should be routinely questioned about concerns related to sexual health and counseled or referred as needed.
●Although data are limited, studies do not indicate increased risk of recurrence for survivors who become pregnant or an impact on pregnancy outcomes.
●For women with breast cancer who wish to preserve fertility but delay pregnancy, we suggest not administering hormonal contraception . Physicians should counsel women about methods most consistent with their lifestyle and beliefs. Alternative forms of contraception include copper IUD and barrier methods.
●A variety of clinicians may adequately follow women after their primary therapy for breast cancer. Clinicians should be experienced in the surveillance of these patients, the complications that may arise from treatment, and in breast examination, including the examination of irradiated breasts. A shared care model that integrates both specialists and primary care providers on ongoing follow-up care may provide the best adherence to guidelines for recommended care; but communication and coordination of care is required.
Single Dose at age > 65 years of age.
Pneumococcal conjugate vaccine (called PCV13) protects against 13 types of pneumococcal bacteria.
PCV13 is routinely given to children at 2, 4, 6, and 12–15 months of age. It is also recommended for children and adults 2 to 64 years of age with certain health conditions, and for all adults 65 years of age and older. Your doctor can give you details.
Anyone who has ever had a life-threatening allergic reaction to a dose of this vaccine, to an earlier pneumococcal vaccine called PCV7, or to any vaccine containing diphtheria toxoid (for example, DTaP), should not get PCV13.
Anyone with a severe allergy to any component of PCV13 should not get the vaccine. Tell your doctor if the person being vaccinated has any severe allergies.
If the person scheduled for vaccination is not feeling well, your healthcare provider might decide to reschedule the shot on another day.
Life style modification: Obesity, Smoking, Alcoholism
Number ONE cause of preventable morbidity in the United States is: TOBACCO. Stop consuming tobacco.
Tertiary: How to help patient when the disease is already here.
Quaternary: Don’t do unnecessary things; Pap tests after the age of 65; Hemoccult after normal colonoscopy. Join ‘Choosing Wisely Campaign’.
-A Great App to see Preventive Health Services. Please go to the following site to download US Preventive Health Services recommendations.
Obesity: BMI over 25, is overweight.
BMI over 30 is Obese.
Watch Weight of the Nation Documentary.
*Physical Activity Guidelines:
Work on muscle groups two or more days of a week.
Moderate Aerobic Activity: 150 minutes/week (Brisk Walking)
Vigorous Aerobic Activity: 75 minutes/week (Jogging or Running)
Acceptable, Men less than or equal to 2 drinks per day; Women less than or equal to 1 drink per day.
You can save 50,000 adult lives per year using vaccines.
In children, 730,000 deaths could be prevented.
=Breastfeeding is NOT a contradiction to vaccines.
=www.aafp.org/Immunizations (Check this website for vaccine recommendations)
=Children with a history of sexual assault should be vaccinated against HPV starting at 9 years of age.
=Tdap is safe during pregnancy.
=Don’t use these vaccines in pregnancy: MMR, Varicella, HPV, Influenza LAV
Heart Failure: Dyspnea and fatigue are main symptoms.
-Heart Failure with reduced Ejection Fraction: Ejection Fraction is < 40 percent.
-Heart Failure with preserved Ejection Fraction, EF >50 percent
-Causes: Hypertension, Amyloidosis, Sarcoidosis, Hemochromatosis, Pericarditis, Valvular disease, atrial myxoma.
-50 of patients with symptoms of heart failure has preserved Ejection Fraction.
-NYHA Functional Classification:
Class 1: No limitation of physical activity.
Class 2: Slight limitation of physical activity.
Class 3: Marked limitation of physical activity.
Class 4: Unable to carry on any physical activity without symptoms of HF. Symptoms of HF at rest.
-BNP: Brain Natriuretic Peptide is secreted from the ventricles in response to ventricular volume expansion and pressure overload. BNP less than 100 excludes HF as cause of shortness of breath.
Preload Reduction: Diuretics, Nitrates
Afterload Reduction: ACE inhibitors, ARBs, Hydralazine, Nitrates.
Sympathetic blockade: Beta blockers
Aldosterone-antagonist therapy: Spironolactone, Eplerenone.
-Renin-Angiotensin System Inhibition by ACE inhibitors and ARBs. Both reduce mortality and morbidity.
-Beta Blockers: Should be started when the patient is stable and euvolemic. There is no absolute threshold ejection fraction where beta-blockers may not be used.
-Spironolactone: reduces mortality, improves ejection fraction.
-Entresto: Valsartan plus Sacubitril can reduce morality.
If you need more information on heart failure, please make an appointment with our physician, Paul Kattupalli MD.