Haemophilus influenzae are pleomorphic, oxidase positive, gram-negative coccobacilli rods that commonly colonize and infect the human respiratory tract.
-H. influenzae are found on the mucous membranes of the upper respiratory tract in humans with the nasopharynx as the most common site of long-term colonization
-Clinically, H. influenzae is similar to S. pneumoniae, with a slower onset.
-it is spread by airborne droplets or by direct contact with secretions or fomites.
-its most serious manifestation is meningitis
-the most prominent strain is Type b
-risk factors include alcoholism, smoking, chronic lung disease, advanced age, and HIV infection
Symptoms & Signs
H influenzae may cause sinusitis, otitis, bronchitis, epiglottitis, pneumonia,pericarditis, cellulitis, arthritis, meningitis, and endocarditis.
Diagnosis can be established by showing gram-negative coccobacilli in culture
Antibiotics: Beta-lactams (amoxicillin, amoxicillin-clavulanate), cephalosporins, fluoroquinolones, macrolides, and tetracyclines
-In Hib meningitis, administration of glucocorticoids reduces the incidence of neurologic sequelae
All children should be immunized with an Hib conjugate vaccine with the primary series at 2–6 months of age, and a booster dose at 12–15 months of age.